Sarcopenia in Older Adults: Unlocking the Synergistic Power of Protein and Mushroom Bioactives
Sarcopenia, the progressive loss of skeletal muscle mass and strength occurring after the sixth decade of life, constitutes a significant public health challenge. This review assesses the current literature on the anti-inflammatory properties of mushroom polysaccharides and their potential to enhanc
The Cordyceps-Andropause Connection: A Review of Testosterone Literature
The age-related decline in testosterone biosynthesis in men has directed scientific attention toward the medicinal fungus Cordyceps, with experimental evidence pointing to a mechanistic pathway that involves stimulation of Leydig cells and modulation of the cyclic adenosine monophosphate (cAMP) sign
Safety of Psilocybin Mushroom Use During the Postpartum Period: A Review of the Literature
Postpartum use of mushrooms in the context of maternal energy depletion, immune adaptations, and lactation safety: a review of existing safety evidence and the species of greatest concern.
Perimenopause and Mushroom Bioactives: A Literature-Based Review
Fluctuating estrogen levels during the perimenopausal transition exert a broad physiological influence, disrupting sleep architecture, mood regulation, and bone metabolism. This entry delineates the current research landscape surrounding bioactive constituents derived from functional mushrooms, situ
Vagus Nerve Signaling and Fungal Bioactives: Mapping the Gut-Brain Axis Literature
The vagus nerve serves as the principal neural conduit between the gut and the brain. As a key component of the autonomic nervous system, it plays a central role in mediating interactions with the gut microbiome, including its fungal constituents, as documented in the scientific literature.
The Hypothalamic-Pituitary-Adrenal Axis and Fungal Adaptogens: A Review of the Evidence
The hypothalamic–pituitary–adrenal (HPA) axis serves as the principal neuroendocrine effector of the stress response. Its signalling cascade proceeds through three hierarchically organised nodes—the paraventricular nucleus of the hypothalamus, the anterior pituitary, and the adrenal cortex—each secr
Astrocytes and Fungal Compounds: A Review of the Glial Support Literature
Astrocytes constitute the most numerous cell type in the human brain. They are integral to glial support functions and the maintenance of the blood–brain barrier. In vitro studies have further characterized their responses to fungal components, expanding the literature on astrocyte–pathogen interact
Adipose Tissue and Mushroom-Derived Compounds: A Review of the Adipogenesis Literature
Adipose tissue functions as a dynamic endocrine organ rather than a passive lipid reservoir. This article outlines the in vitro literature on white, brown, and beige adipocyte subtypes and their interactions with bioactive fungal constituents.
Pancreatic Beta Cells and Fungal Polysaccharides: A Review of the Literature
The architecture of pancreatic β-cells, the molecular biology of insulin, and the treatment of fungal polysaccharides in the in vitro cell culture literature.
Reishi and Cordyceps: A Comparative Analysis of Adaptogenic Properties
Reishi and Cordyceps represent two distinct chemical identities: the triterpenoid-rich profile of Ganoderma lucidum contrasts with the nucleoside-dominated chemistry of Cordyceps species, yielding divergent frameworks of traditional use and sharply differing in vitro research landscapes.
